FcRγ Gene Editing Reprograms Conventional NK Cells to Display Key Features of Adaptive Human NK Cells

Summary: Adaptive human natural killer (NK) cells display significantly enhanced responsiveness to a broad-range of antibody-bound targets through the engagement of CD16 compared to conventional NK cells, yet direct reactivity against tumor targets is generally reduced. Adaptive NK cells also displa...

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Bibliographic Details
Main Authors: Weiru Liu, Jeannine M. Scott, Emma Langguth, Helena Chang, Peter H. Park, Sungjin Kim
Format: Artigo
Language:Inglês
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309068
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