Methylprednisolone protects cardiac pumping mechanics from deteriorating in lipopolysaccharide-treated rats

It has been shown that a prolonged low-dose corticosteroid treatment attenuates the severity of inflammation and the intensity and duration of organ system failure. In the present study, we determined whether low-dose methylprednisolone (a synthetic glucocorticoid) can protect male Wistar rats again...

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Main Authors: Ya-Hui eKo, Ming-Shian eTsai, Ru-Wen eChang, Chun-Yi eChang, Chih-Hsien eWang, Ming-Shiou eWu, Jin-Tung eLiang, Kuo-Chu eChang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-11-01
Colecção:Frontiers in Physiology
Assuntos:
Inflammation
Malondialdehyde
peroxynitrite
High-mobility group box 1
maximal systolic elastance
theoretical maximum flow
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00348/full
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