Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

Abstract Background Several lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer’s disease (AD) risk by decreasing vascular beta-amyloid (Aβ) deposition and inflammation, however, the mechanisms by which HDL improve cerebrovascular functions relevant to AD remain poorly un...

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Main Authors: Jerome Robert, Emily B. Button, Emma M. Martin, Luke McAlary, Zoe Gidden, Megan Gilmour, Guilaine Boyce, Tara M. Caffrey, Andrew Agbay, Amanda Clark, Judith M. Silverman, Neil R. Cashman, Cheryl L. Wellington
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2020-03-01
Series:Molecular Neurodegeneration
Assuntos:
Alzheimer’s disease
Cerebrovasculature
High-density lipoprotein (HDL)
Cerebral amyloid angiopathy (CAA)
Endothelial inflammation
Apolipoprotein (apo)E
Acceso en liña:http://link.springer.com/article/10.1186/s13024-020-00366-8
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