Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase

Abstract Background Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparaginase; however, the mechanism underlying their inter-individual difference...

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Detalhes bibliográficos
Main Authors: Katerina Hlozkova, Alena Pecinova, Natividad Alquezar-Artieda, David Pajuelo-Reguera, Marketa Simcikova, Lenka Hovorkova, Katerina Rejlova, Marketa Zaliova, Tomas Mracek, Alexandra Kolenova, Jan Stary, Jan Trka, Julia Starkova
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-06-01
Colecção:BMC Cancer
Assuntos:
cancer metabolism
L-asparaginase
leukemia
resistance
glycolysis
mitochondrial respiration
Acesso em linha:http://link.springer.com/article/10.1186/s12885-020-07020-y
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