Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21.

Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression levels of ORMDL3, GSDMB and ZPBP2 genes. Remarkably, ORMDL3 has been shown t...

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Bibliographic Details
Main Authors: Amado Carreras-Sureda, Fanny Rubio-Moscardo, Alex Olvera, Jordi Argilaguet, Kerstin Kiefer, Beatriz Mothe, Andreas Meyerhans, Christian Brander, Rubén Vicente
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5106028?pdf=render
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