Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice

Platelet collagen interactions at sites of vascular injuries predominantly involve glycoprotein VI (GPVI) and the integrin α2β1. Both proteins are primarily expressed on platelets and megakaryocytes whereas GPVI expression is also shown on endothelial and integrin α2&#...

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Detalhes bibliográficos
Main Authors: Michael K. Schuhmann, Peter Kraft, Michael Bieber, Alexander M. Kollikowski, Harald Schulze, Bernhard Nieswandt, Mirko Pham, David Stegner, Guido Stoll
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-04-01
Colecção:International Journal of Molecular Sciences
Assuntos:
ischemic stroke
integrin α2
glycoprotein VI
recombinant tissue-type plasminogen activator
intracranial bleeding
transient middle cerebral artery occlusion
Acesso em linha:https://www.mdpi.com/1422-0067/20/8/2019
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