A rapid LC-MS/MS assay for detection and monitoring of underivatized branched-chain amino acids in maple syrup urine disease

Introduction: Quantitation of the isomeric branched-chain amino acids (BCAA; valine, alloisoleucine, isoleucine, leucine) is a challenging task that typically requires derivatization steps or long runtimes if a traditional chromatographic method involving a ninhydrin ion pairing reagent is used. Obj...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Hamed Piri-Moghadam, Alan Miller, Debra Pronger, Faye Vicente, Joel Charrow, Shannon Haymond, David C. Lin
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2022-04-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
Assuntos:
Mass spectrometry
Branched-chain amino acid
Quantitation
Maple syrup urine disease
Clinical assay
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2667145X22000116
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares