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Intensive mutagenesis of the nisin hinge leads to the rational design of enhanced derivatives.

Nisin A is the most extensively studied lantibiotic and has been used as a preservative by the food industry since 1953. This 34 amino acid peptide contains three dehydrated amino acids and five thioether rings. These rings, resulting from one lanthionine and four methyllanthionine bridges, confer t...

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Main Authors: Brian Healy, Des Field, Paula M O'Connor, Colin Hill, Paul D Cotter, R Paul Ross
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science (PLoS) 2013-01-01
Sraith:PLoS ONE
Rochtain Ar Líne:http://europepmc.org/articles/PMC3823697?pdf=render
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