Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole. Centriole engagement is known to block the reduplication of mother centrioles, but the molecu...

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Библиографические подробности
Главные авторы: Minhee Kim, Brian P. O’Rourke, Rajesh Kumar Soni, Prasad V. Jallepalli, Ronald C. Hendrickson, Meng-Fu Bryan Tsou
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2016-08-01
Серии:Cell Reports
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2211124716308385
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