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Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole. Centriole engagement is known to block the reduplication of mother centrioles, but the molecu...

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Xehetasun bibliografikoak
Egile Nagusiak: Minhee Kim, Brian P. O’Rourke, Rajesh Kumar Soni, Prasad V. Jallepalli, Ronald C. Hendrickson, Meng-Fu Bryan Tsou
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2016-08-01
Saila:Cell Reports
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2211124716308385
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