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Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole. Centriole engagement is known to block the reduplication of mother centrioles, but the molecu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Minhee Kim, Brian P. O’Rourke, Rajesh Kumar Soni, Prasad V. Jallepalli, Ronald C. Hendrickson, Meng-Fu Bryan Tsou
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2016-08-01
Cyfres:Cell Reports
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2211124716308385
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