Early Stage Alterations in White Matter and Decreased Functional Interhemispheric Hippocampal Connectivity in the 3xTg Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even before the appearance of the classical neuropathologic...

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Main Authors: Francis A. M. Manno, Arturo G. Isla, Sinai H. C. Manno, Irfan Ahmed, Shuk Han Cheng, Fernando A. Barrios, Condon Lau
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-03-01
Serier:Frontiers in Aging Neuroscience
Fag:
Alzheimer’s disease (AD)
3xTg-AD mouse model
diffusion tensor imaging (DTI)
resting-state functional magnetic resonance imaging (rsfMRI)
fractional anisotropy
radial diffusivity
Online adgang:https://www.frontiersin.org/article/10.3389/fnagi.2019.00039/full
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