Anti-Gr-1 Antibody Provides Short-Term Depletion of MDSC in Lymphodepleted Mice with Active-Specific Melanoma Therapy

Lymphodepletion, reconstitution and active-specific tumor cell vaccination (LRAST) enhances the induction of tumor-specific T cells in a murine melanoma model. Myeloid-derived suppressor cells (MDSC) may counteract the induction of tumor-reactive T cells and their therapeutic efficacy. Thus, the aim...

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Main Authors: Peter Rose, Natasja K. van den Engel, Julia R. Kovács, Rudolf A. Hatz, Louis Boon, Hauke Winter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Vaccines
Assuntos:
immunotherapy
vaccination
myeloid-derived suppressor cells
melanoma
T-Lymphocytes
Acesso em linha:https://www.mdpi.com/2076-393X/10/4/560
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