Development and validation of a HPLC-UV method for methadone hydrochloride quantification in a new oral solution with preservatives to be implemented in physicochemical stability studies

Abstract Purpose The Pharmacy Service of the Infanta Leonor University Hospital acquires, compounds, distributes and dispenses more than 3000 L of methadone oral solution to Drug Addiction Patients Centers per year. Our purpose is to develop and validate an improved high performance liquid chromatog...

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Main Authors: Elena Alba Álvaro-Alonso, Mª Paz Lorenzo, Ismael Escobar-Rodríguez, Antonio Aguilar-Ros
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
Colecção:BMC Chemistry
Assuntos:
Methadone hydrochloride
Pharmaceutical solutions
Drug compounding
High performance liquid chromatography
Analysis
Analytical chemistry method
Acesso em linha:https://doi.org/10.1186/s13065-022-00827-9
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