Frequent retrotransposition of endogenous genes in ERCC2-deficient cells derived from a patient with xeroderma pigmentosum

Abstract Background Retrotransposition of protein-coding genes is thought to occur due to the existence of numerous processed pseudogenes in both animals and plants. Unlike retrotransposons including Alu and LINE-1, direct evidence of such retrotransposition events has not been reported to date. Eve...

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Main Authors: Saki Aoto, Saki Katagiri, Yi Wang, Alistair T. Pagnamenta, Rie Sakamoto-Abutani, Masashi Toyoda, Akihiro Umezawa, Kohji Okamura
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Assuntos:
Retrotransposition
ERCC2
XPA
Xeroderma pigmentosum
DNA repair
Somatic mutation
Acceso en liña:http://link.springer.com/article/10.1186/s13287-019-1381-z
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