Medullary Thyroid Carcinoma Mutational Spectrum Update and Signaling-Type Inference by Transcriptional Profiles: Literature Meta-Analysis and Study of Tumor Samples

Medullary thyroid carcinoma (MTC) is a rare but aggressive tumor. Although <i>RET</i> and <i>RAS</i> genes are recognized drivers in MTC, associated downstream signaling pathways are largely unknown. In this study, we report 17 sporadic MTCs, collected at our institution, com...

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Detalhes bibliográficos
Main Authors: Emanuela Minna, Paola Romeo, Matteo Dugo, Loris De Cecco, Antonella Aiello, Federico Pistore, Andrea Carenzo, Angela Greco, Maria Grazia Borrello
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Cancers
Assuntos:
medullary thyroid cancer
transcriptomics
<i>RET</i> deletions
genetic landscape
meta-analysis
Acesso em linha:https://www.mdpi.com/2072-6694/14/8/1951
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