Neurotoxic Effects of Platinum Compounds: Studies in vivo on Intracellular Calcium Homeostasis in the Immature Central Nervous System

Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological complications especially in paediatric oncology patients with Central Nervous System (CNS) and non-CNS malignancies. To understand the toxicity mechanisms of platinum drugs at cellular and molecular l...

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Main Authors: Graziella Bernocchi, Francesco P. Fanizzi, Sandra A. De Pascali, Valeria M. Piccolini, Caterina Gasperini, Violetta Insolia, Maria Grazia Bottone
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2015-06-01
Serier:Toxics
Fag:
platinum compounds
neurotoxicity
CNS development
calcium homeostasis systems
purkinje neurons
dentate granule cells
Online adgang:http://www.mdpi.com/2305-6304/3/2/224
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