<i>In Silico</i> Profiling of Clinical Phenotypes for Human Targets Using Adverse Event Data

We present a novel approach for the molecular transformation and analysis of patient clinical phenotypes. Building on the fact that drugs perturb the function of targets/genes, we integrated data from 8.2 million clinical reports detailing drug-induced side effects with the molecular world of drug-t...

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Detalhes bibliográficos
Main Authors: Theodoros G. Soldatos, Guillaume Taglang, David B. Jackson
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-11-01
Colecção:High-Throughput
Assuntos:
computational biology
large-scale approaches
systems pharmacology
adverse events
side-effects
outcome analytics
real world data
mode of action
clinical phenotypes
phenotypic screening
drug safety prediction
Acesso em linha:https://www.mdpi.com/2571-5135/7/4/37
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