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A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
<p>Abstract</p> <p>Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma receptors (FcgR) on human white blood cells are an integral part of the ADCC pathway....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2013-01-01
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| Colecção: | Journal of Hematology & Oncology |
| Assuntos: | |
| Acesso em linha: | http://www.jhoonline.org/content/6/1/1 |
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