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Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuse.

A promising strategy for drug abuse treatment is to accelerate the drug metabolism by administration of a drug-metabolizing enzyme. The question is how effectively an enzyme can actually prevent the drug from entering brain and producing physiological effects. In the present study, we have developed...

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Bibliografske podrobnosti
Main Authors: Fang Zheng, Chang-Guo Zhan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2012-01-01
Serija:PLoS Computational Biology
Online dostop:http://europepmc.org/articles/PMC3406004?pdf=render
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