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Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins

We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses have not been elucidated yet. We have investigate...

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Autors principals: Kirtikar Shukla, Pabitra Bikash Pal, Himangshu Sonowal, Satish K. Srivastava, Kota V. Ramana
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Limited 2017-01-01
Col·lecció:Journal of Diabetes Research
Accés en línia:http://dx.doi.org/10.1155/2017/6785852
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