Dectin-1 Promotes Type I and III Interferon Expression to Support Optimal Antifungal Immunity in the Lung

Pulmonary infections with Aspergillus fumigatus (Af) are a significant cause of invasive fungal disease and lead to high morbidity and mortality in diverse populations throughout the world. Currently available antifungal drugs are often ineffective, thus contributing to unacceptably high mortality r...

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Main Authors: Orchi Dutta, Vanessa Espinosa, Keyi Wang, Samantha Avina, Amariliz Rivera
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-07-01
Serier:Frontiers in Cellular and Infection Microbiology
Fag:
Aspergillus
dectin-1
β-glucan
cell wall
innate immunity
IFN-λ
Online adgang:https://www.frontiersin.org/article/10.3389/fcimb.2020.00321/full
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