A large pooled analysis refines gene expression-based molecular subclasses in cutaneous melanoma

This study aimed to establish the number of expression-based molecular subclasses in cutaneous melanoma, identify their dominant biological pathways and evaluate their clinical relevance. To this end, consensus clustering was performed separately on two independent datasets (n = 405 and n = 473) com...

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Detalhes bibliográficos
Main Authors: Thijs T. Wind, Mathilde Jalving, Jacco J. de Haan, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Dirk-Jan Reijngoud, Rozemarijn S. van Rijn, John B. A. G. Haanen, Christian U. Blank, Geke A. P. Hospers, Rudolf S. N. Fehrmann
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2019-03-01
Colecção:OncoImmunology
Assuntos:
cutaneous melanoma
gene expression
consensus clustering
pooled analysis
molecular classification
anti-pd-1 therapy
Acesso em linha:http://dx.doi.org/10.1080/2162402X.2018.1558664
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