Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy

Nuclear export protein 1 (XPO1), a member of the nuclear export protein-p (Karyopherin-P) superfamily, regulates the transport of “cargo” proteins. To facilitate this important process, which is essential for cellular homeostasis, XPO1 must first recognize and bind the cargo proteins. To inhibit thi...

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מידע ביבליוגרפי
Main Authors: Zheyuan Shen, Weihao Zhuang, Kang Li, Yu Guo, Bingxue Qu, Sikang Chen, Jian Gao, Jing Liu, Lei Xu, Xiaowu Dong, Jinxin Che, Qimeng Li
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-04-01
סדרה:Molecules
נושאים:
nuclear export protein 1
hybrid virtual screening
covalent docking
anti-tumor
גישה מקוונת:https://www.mdpi.com/1420-3049/27/8/2543
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