Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro

Malignant cells acquire physiological mechanisms of immunosuppression to escape immune surveillance. Strategies to counteract this suppression could help to improve adoptive immunotherapy regimen. The intracellular second messenger cyclic AMP (cAMP) acts as a potent immunosuppressive signaling molec...

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Main Authors: Klaus G. Schmetterer, Katrin Goldhahn, Liesa S. Ziegler, Marlene C. Gerner, Ralf L. J. Schmidt, Madeleine Themanns, Eva Zebedin-Brandl, Doris Trapin, Judith Leitner, Winfried F. Pickl, Peter Steinberger, Ilse Schwarzinger, Rodrig Marculescu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-07-01
Colecção:Frontiers in Immunology
Assuntos:
immune tolerance
checkpoint inhibitor
adoptive immunotherapy
tumor immunosuppression
T-cell engineering
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.01790/full
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