Ex vivo Detection and Characterization of Hepatitis B Virus-Specific CD8+ T Cells in Patients Considered Immune Tolerant

In this study, we aimed to detect and characterize ex vivo virus-specific CD8+ T cells in patients with immune-tolerant hepatitis B virus (HBV) infection. We investigated a Korean chronic hepatitis B cohort composed of 15 patients in the immune-tolerant phase, 17 in the immune-active phase, and 13 u...

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Main Authors: Pil Soo Sung, Dong Jun Park, Jung-Hee Kim, Ji Won Han, Eun Byul Lee, Gil Won Lee, Hee Chul Nam, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Eui-Cheol Shin, Su-Hyung Park, Seung Kew Yoon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-06-01
Colecção:Frontiers in Immunology
Assuntos:
hepatitis B virus
CD8+ T-cell response
programmed death protein-1
chronic infection
interferon-γ
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.01319/full
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