DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

Abstract Background Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the heterogeneity of the D...

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Main Authors: H. Binder, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. T. W. Jones, S. M. Pfister, M. Kreuz, D. Gramatzki, E. Fortenbacher, B. Hentschel, M. Tatagiba, U. Herrlinger, H. Vatter, J. Matschke, M. Westphal, D. Krex, G. Schackert, J. C. Tonn, U. Schlegel, H.-J. Steiger, W. Wick, R. G. Weber, M. Weller, M. Loeffler
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-04-01
Colecção:Acta Neuropathologica Communications
Assuntos:
Glioma
Molecular subtypes
DNA methylation
Epigenetics
Astrocytoma
Tumor microenvironment
Acesso em linha:http://link.springer.com/article/10.1186/s40478-019-0704-8
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