Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial [version 1; referees: 2 approved]

Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and experimental data suggest that copper may increase its anti-neoplastic propert...

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Hauptverfasser: Asgeir Store Jakola, Katja Werlenius, Munila Mudaisi, Sofia Hylin, Sara Kinhult, Jiri Bartek Jr., Øyvind Salvesen, Sven Magnus Carlsen, Michael Strandéus, Magnus Lindskog, David Löfgren, Bertil Rydenhag, Louise Carstam, Sasha Gulati, Ole Solheim, Jiri Bartek, Tora Solheim
Format: Artigo
Sprache:Inglês
Veröffentlicht: F1000 Research Ltd 2018-11-01
Schriftenreihe:F1000Research
Online Zugang:https://f1000research.com/articles/7-1797/v1
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