Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model

Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau) in presynaptic terminals at 10–20 µM caused...

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Main Authors: Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications Ltd 2022-04-01
Serija:eLife
Teme:
tau
excitatory synaptic transmission
calyx of Held presynaptic terminal
microtubule
dynamin
endocytosis
Online dostop:https://elifesciences.org/articles/73542
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