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Structure-Based Virtual Screening towards the Discovery of Novel ULK1 Inhibitors with Anti-HCC Activities

There is an urgent need to develop new effective therapies for HCC. Our previous study identified ULK1 as the potential target for HCC therapy and screened the compound XST-14 as a specific inhibitor of ULK1 to suppress HCC progression. However, the poor manufacturability of XST-14 impeded the proce...

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Detalhes bibliográficos
Main Authors: Yang Gao, Ziying Zhou, Tingting Zhang, Situ Xue, Ke Li, Jiandong Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Molecules
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Acesso em linha:https://www.mdpi.com/1420-3049/27/9/2627
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