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Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?

The type 5 metabotropic glutamate receptor, mGlu5, has been proposed as a potential therapeutic target for the treatment of several neurodegenerative diseases. In preclinical neurodegenerative disease models, novel allosteric modulators have been shown to improve cognitive performance and reduce dis...

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Autori principali: Rebecca F. Budgett, Geor Bakker, Eugenia Sergeev, Kirstie A. Bennett, Sophie J. Bradley
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-05-01
Serie:Frontiers in Pharmacology
Soggetti:
GPCR
Alzheimer’s disease
neurodegenerative disease
neuroinflammation
G protein coupled receptors
drug discovery
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2022.893422/full
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