Population Pharmacokinetics of Mycophenolic Acid in Renal Transplant Patients: A Comparison of the Early and Stable Posttransplant Stages

Mycophenolic acid (MPA) is an antimetabolic immunosuppressive drug widely used in solid organ transplantation and autoimmune diseases. Pharmacokinetics (PK) of MPA demonstrates high inter- and intra-variability. The aim of this study was to compare the population PK properties of MPA in adult renal...

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Bibliographic Details
Main Authors: Peile Wang, Hongchang Xie, Qiwen Zhang, Xueke Tian, Yi Feng, Zifei Qin, Jing Yang, Wenjun Shang, Guiwen Feng, Xiaojian Zhang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
mycophenolic acid
population pharmacokinetics
post-transplant periods
AUC
renal transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.859351/full
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