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Role of DNA Polymerases in Repeat-Mediated Genome Instability
Expansions of simple DNA repeats cause numerous hereditary diseases in humans. We analyzed the role of DNA polymerases in the instability of Friedreich’s ataxia (GAA)n repeats in a yeast experimental system. The elementary step of expansion corresponded to ∼160 bp in the wild-type strain, matching t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2012-11-01
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| Colecção: | Cell Reports |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2211124712003427 |
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