Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline

Chun-Yu Lo,1 Hung-Yu Huang,1 Jung-Ru He,1 Tzu-Ting Huang,1 Chih-Chen Heh,1 Te-Fang Sheng,1 Kian Fan Chung,2 Han-Pin Kuo,1 Chun-Hua Wang1 1Department of Thoracic Medicine, Chang Gung Medical Foundation, College of Medicine, Chang Gung University, Taipei, Taiwan; 2Airways Disease Section, National He...

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Detalhes bibliográficos
Main Authors: Lo CY, Huang HY, He JR, Huang TT, Heh CC, Sheng TF, Chung KF, Kuo HP, Wang CH
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018-04-01
Colecção:International Journal of COPD
Assuntos:
Smoking
airway hyperresponsiveness (AHR)
alveolar macrophage (AM)
matrix metalloproteinase-9 (MMP)-9
tissue inhibitor of metalloproteinase-1 (TIMP-1)
p38 mitogen-activated protein kinase (MAPK)
extracellular signal-regulated kinase (ERK).
Acesso em linha:https://www.dovepress.com/increased-matrix-metalloproteinase-9-to-tissue-inhibitor-of-metallopro-peer-reviewed-article-COPD
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