Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1

Mesenchymal stem cells (MSCs) therapy shows the potential benefits to relieve clinical symptoms of osteoarthritis (OA), but it is uncertain if it can repair articular cartilage lesions — the main pathology of OA. Here, we prepared biomimetic cupper sulfide@phosphatidylcholine (CuS@PC) nanoparticles...

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Detalhes bibliográficos
Main Authors: Yu Cai, Cuixi Wu, Qianhua Ou, Muhui Zeng, Song Xue, Jieli Chen, Yao Lu, Changhai Ding
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Communications Co., Ltd. 2023-01-01
Colecção:Bioactive Materials
Assuntos:
Osteoarthritis
Stem cell therapy
Cartilage regeneration
Cupper sulfide nanoparticles
Gene delivery
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2452199X22001918
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