Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells

Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the re...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Andrzej Kutner, Joanna Wietrzyk, Krzysztof Krajewski, Małgorzata Krupa, Beata Filip-Psurska, Agnieszka Martowicz, Michał Chodyński, Magdalena Milczarek
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2013-10-01
Sarja:Cancers
Aiheet:
calcipotriol
vitamin D analogs
convergent synthesis
antiproliferative activity
cancer
combined treatment
VDR
Linkit:http://www.mdpi.com/2072-6694/5/4/1355
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