Impact of APOE ε4 Carrier Status on Associations Between Subthreshold, Positive Amyloid-β Deposition, Brain Function, and Cognitive Performance in Cognitively Normal Older Adults: A Prospective Study

BackgroundA growing body of evidence suggests a deteriorating effect of subthreshold amyloid-beta (Aβ) accumulation on cognition before the onset of clinical symptoms of Alzheimer's disease (AD). Despite the association between the Aβ-dependent pathway and the APOE ε4 allele, the impact of this...

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Autors principals: Dong Woo Kang, Sheng-Min Wang, Yoo Hyun Um, Nak-Young Kim, Chang Uk Lee, Hyun Kook Lim
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2022-05-01
Col·lecció:Frontiers in Aging Neuroscience
Matèries:
APOE ε4 allele
subthreshold amyloid-beta
regional homogeneity
functional connectivity
cognitively normal older adults
Accés en línia:https://www.frontiersin.org/articles/10.3389/fnagi.2022.871323/full
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