Exploiting the Metabolic Consequences of PTEN Loss and Akt/Hexokinase 2 Hyperactivation in Prostate Cancer: A New Role for δ-Tocotrienol

The Warburg effect is commonly recognized as a hallmark of nearly all tumors. In prostate cancer (PCa), it has been shown to be driven by PTEN loss- and Akt hyperactivation-associated upregulation of hexokinase 2 (HK2). δ-Tocotrienol (δ-TT) is an extensively studied antitumor compound; however, its...

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Bibliographic Details
Main Authors: Fabrizio Fontana, Martina Anselmi, Patrizia Limonta
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
tocotrienols
Warburg effect
glycolysis
hexokinase 2
Akt
Online Access:https://www.mdpi.com/1422-0067/23/9/5269
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