Inhibition of excessive mitophagy by N-acetyl-L-tryptophan confers hepatoprotection against Ischemia-Reperfusion injury in rats

In order to investigate the mechnism of hepatoprotective of N-acetyl-L-tryptophan (L-NAT) against ischemia-reperfusion (I/R) injury, the effects of L-NAT were investigated in hepatic ischemia-reperfusion injury (HIRI) models both in vitro and in vivo, which were made by BRL cells and Sprague-Dawley...

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Detalhes bibliográficos
Main Authors: Huiting Li, Yitong Pan, Hongjuan Wu, Shuna Yu, Jianxin Wang, Jie Zheng, Can Wang, Jianguo Li, Jiying Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2020-04-01
Colecção:PeerJ
Assuntos:
Hepatic ischemia-reperfusion injury
H2O2
N-acetyl-L-tryptophan
Mitophagy
Acesso em linha:https://peerj.com/articles/8665.pdf
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