N-terminal selective conjugation method widens the therapeutic window of antibody–drug conjugates by improving tolerability and stability

Antibody–drug conjugates (ADCs) are targeted therapeutic agents that treat cancers by selective delivery of highly potent cytotoxic drugs to tumor cells via cancer-specific antibodies. However, their clinical benefit is limited by off-target toxicity and narrow therapeutic windows. To overcome these...

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Main Authors: Min Ji Ko, Daehae Song, Juhee Kim, Jae Yong Kim, Jaehyun Eom, Byungje Sung, Yong-Gyu Son, Young Min Kim, Sang Hoon Lee, Weon-Kyoo You, Jinwon Jung
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2021-01-01
Colecção:mAbs
Assuntos:
Antibody–drug conjugate
N-terminal conjugation
therapeutic window
toxicity
stability
trastuzumab
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2021.1914885
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