High Exploratory Phenotype Rats Exposed to Environmental Stressors Present Memory Deficits Accompanied by Immune-Inflammatory/Oxidative Alterations: Relevance to the Relationship Between Temperament and Mood Disorders

Low-exploratory (LE) and high-exploratory (HE) rodents mimic human depressive and hyperthymic temperaments, respectively. Mood disorders (MD) may be developed by the exposure of these temperaments to environmental stress (ES). Psychiatric symptoms severity in MD patients is related to the magnitude...

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Main Authors: Camila Nayane de Carvalho Lima, Francisco Eliclécio Rodrigues da Silva, Adriano José Maia Chaves Filho, Ana Isabelle de Gois Queiroz, Adriana Mary Nunes Costa Okamura, Gabriel Rodrigo Fries, João Quevedo, Francisca Cléa F de Sousa, Silvania Maria Mendes Vasconcelos, David F de Lucena, Marta Maria de França Fonteles, Danielle S. Macedo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-08-01
Colecção:Frontiers in Psychiatry
Assuntos:
temperament
animal model
bipolar disorder
paradoxical sleep deprivation
unpredictable stress
neuroinflammation
Acesso em linha:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00547/full
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