Small-Molecule Immunosuppressive Drugs and Therapeutic Immunoglobulins Differentially Inhibit NK Cell Effector Functions in vitro

Small-molecule immunosuppressive drugs (ISD) prevent graft rejection mainly by inhibiting T lymphocytes. Therapeutic immunoglobulins (IVIg) are used for substitution, antibody-mediated rejection (AbMR) and HLA-sensitized recipients by targeting distinct cell types. Since the effect of ISD and IVIg o...

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Main Authors: Amandine Pradier, Maria Papaserafeim, Ning Li, Anke Rietveld, Charlotte Kaestel, Lyssia Gruaz, Cédric Vonarburg, Rolf Spirig, Gisella L. Puga Yung, Jörg D. Seebach
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-03-01
Colecção:Frontiers in Immunology
Assuntos:
human NK cells
immunosuppression
cytotoxicity and ADCC
IVIg
methylprednisolone
mycophenolic acid
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.00556/full
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