Projection to Latent Spaces Disentangles Pathological Effects on Brain Morphology in the Asymptomatic Phase of Alzheimer's Disease

Alzheimer's disease (AD) continuum is defined as a cascade of several neuropathological processes that can be measured using biomarkers, such as cerebrospinal fluid (CSF) levels of Aβ, p-tau, and t-tau. In parallel, brain anatomy can be characterized through imaging techniques, such as magnetic...

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Detalhes bibliográficos
Main Authors: Adrià Casamitjana, Paula Petrone, José Luis Molinuevo, Juan Domingo Gispert, Verónica Vilaplana
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-07-01
Colecção:Frontiers in Neurology
Assuntos:
Alzheimer's disease
PLS
pre-clinical AD
latent model
CSF biomarkers
brain morphology
Acesso em linha:https://www.frontiersin.org/article/10.3389/fneur.2020.00648/full
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