α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells

Abstract Tamoxifen resistance (TamR) is the underlying cause of treatment failure in many breast cancer patients receiving tamoxifen. In order to look for noncytotoxic natural products with the ability to reverse TamR, an extract from strain Streptomyces sp. KIB-H0495 was detected to be active. Subs...

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Main Authors: Rui-Min Yang, Xiu-Lei Zhang, Li Wang, Jian-Ping Huang, Jing Yang, Yi-Jun Yan, Jian-Ying Luo, Xiang-Ting Wang, Sheng-Xiong Huang
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2017-06-01
Colecção:Natural Products and Bioprospecting
Assuntos:
Breast cancer
Tamoxifen resistance
Resensitization
α-Pyrone derivatives
Streptomyces
Acesso em linha:http://link.springer.com/article/10.1007/s13659-017-0136-8
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