The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma

Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary infections during hospitalization and after hospital discharge. Studies show that the mitochondrial function and oxidative metabolism of monocytes and macrophages are impaired during sepsis. Alternatively, t...

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Bibliographic Details
Main Authors: Margaret A. McBride, Allison M. Owen, Cody L. Stothers, Antonio Hernandez, Liming Luan, Katherine R. Burelbach, Tazeen K. Patil, Julia K. Bohannon, Edward R. Sherwood, Naeem K. Patil
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
sepsis
infection
trauma
trained immunity
mitochondria
metabolic reprogramming
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01043/full
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