The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma

Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary infections during hospitalization and after hospital discharge. Studies show that the mitochondrial function and oxidative metabolism of monocytes and macrophages are impaired during sepsis. Alternatively, t...

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Autori principali: Margaret A. McBride, Allison M. Owen, Cody L. Stothers, Antonio Hernandez, Liming Luan, Katherine R. Burelbach, Tazeen K. Patil, Julia K. Bohannon, Edward R. Sherwood, Naeem K. Patil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-05-01
Serie:Frontiers in Immunology
Soggetti:
sepsis
infection
trauma
trained immunity
mitochondria
metabolic reprogramming
Accesso online:https://www.frontiersin.org/article/10.3389/fimmu.2020.01043/full
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