Baseline levels of dynamic CD4+ T cell adhesion to MAdCAM-1 correlate with clinical response to vedolizumab treatment in ulcerative colitis: a cohort study

Abstract Background While the number of therapeutic options for treating inflammatory bowel diseases (IBD) is increasing, evidence for rational treatment decisions is scarce in many cases. In particular, appropriate biomarkers to predict the response to the anti-α4β7 integrin antibody vedolizumab ar...

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Bibliographic Details
Main Authors: Clarissa Allner, Michaela Melde, Emily Becker, Friederike Fuchs, Laura Mühl, Entcho Klenske, Lisa Müller, Nadine Morgenstern, Konstantin Fietkau, Simon Hirschmann, Raja Atreya, Imke Atreya, Markus F. Neurath, Sebastian Zundler
Format: Artigo
Language:Inglês
Published: BMC 2020-04-01
Series:BMC Gastroenterology
Subjects:
Inflammatory bowel diseases
T cells
Vedolizumab
Adhesion
Gut homing
Online Access:http://link.springer.com/article/10.1186/s12876-020-01253-8
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