Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1

Abstract Background Accumulating evidence has highlighted the tumor suppressive roles of microRNA (miRNAs) in cervical cancer (CC). In the present study, we aim to delineate the functional relevance of microRNA-137 (miR-137) in influencing epithelial–mesenchymal transition (EMT), and other CC cell b...

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Main Authors: Hui Miao, Nuan Wang, Lin-Xin Shi, Zheng Wang, Wen-Bo Song
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-05-01
Colecção:Cancer Cell International
Assuntos:
MicroRNA-137
Cervical cancer
GREM1
TGF-β/smad pathway
Epithelial–mesenchymal transition
Invasion
Acesso em linha:http://link.springer.com/article/10.1186/s12935-019-0852-8
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