The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity

A mismatch between β-oxidation and the tricarboxylic acid cycle (TCA) cycle flux in mitochondria produces an accumulation of lipid metabolic intermediates, resulting in both blunted metabolic flexibility and decreased glucose utilization in the affected cells. The ability of the cell to switch to gl...

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Auteurs principaux: Francesca Di Cristo, Anna Calarco, Filomena Anna Digilio, Maria Stefania Sinicropi, Camillo Rosano, Umberto Galderisi, Mariarosa Anna Beatrice Melone, Carmela Saturnino, Gianfranco Peluso
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2020-10-01
Collection:International Journal of Molecular Sciences
Sujets:
carnitine system
carnitine/organic cation transporter (OCTN2)
mitochondrial β-oxidation
Huntington’s disease (HD)
meldonium
Accès en ligne:https://www.mdpi.com/1422-0067/21/19/7431
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