Isolating Human Monoclonal Antibodies Against Adeno-Associated Virus From Donors With Pre-existing Immunity

With the advent of single B-cell cloning technology, we can isolate antibodies against virtually any antigen to study the interaction of a given pathogen with the immune system and develop novel therapeutic strategies. Antibodies directed against the capsid of adeno-associated viruses (AAV) are a si...

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Principais autores: April R. Giles, Roberto Calcedo, Anna P. Tretiakova, James M. Wilson
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-07-01
coleção:Frontiers in Immunology
Assuntos:
adeno-associated virus
human monoclonal antibody
memory B-cell
single cell cloning
vector engineering
gene therapy
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.01135/full
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