Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O2 Sensitive Voltage-Gated K+ Channels

Background: The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are not fully elucidated in relation to receptor subtype a...

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Autori principali: Fenling Fan, Hua Tian, Jie Geng, Jizhao Deng, Ya Liu, Chunyan Chen, Songlin Zhang, Yushun Zhang, Jie Li, Hongyan Tian, Anthony M. Dart, Yuliang Zou
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019-01-01
Serie:Frontiers in Pharmacology
Soggetti:
pulmonary arterial hypertension
prostanoids
Beraprost
IP receptor
EP4 receptor
Kv channel
Accesso online:https://www.frontiersin.org/article/10.3389/fphar.2018.01518/full
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